EPA / USP / ENVIRONMENTAL CALIBRATION STANDARDS
Multi-element calibration standards for ICP-OES and ICP-MS, compliant with EPA 200.7, EPA 200.8, USP 232/233, and environmental methods. Groundwater, wastewater, and pharmaceutical applications covered — with ICV, CRQL, and CRDL quality control solutions included.
EPA Methodology
All calibration and quality control solutions required by EPA 200.7 and EPA 200.8 are available from a single source.
Standard Catalog
All EPA, USP, and environmental standards are available in 125 mL and 500 mL bottle sizes.
| Standard | Elements | 125 mL | 500 mL | Matrix |
|---|---|---|---|---|
| Complete Set (Std 1–5) | Ca, Mg, K, Na, Al, As, Cr, Sb, Se, V, Ba, Be, Cu, Fe | 140-120-061 | 140-120-065 | 5% HNO₃ |
| Mixed Standard 1 | Ca, Mg, K, Na (cation group) | 140-120-011 | 140-120-015 | 5% HNO₃ |
| Mixed Standard 4 | Ag, Cr, Mn, Zn, Ni (trace metals) | 140-120-041 | 140-120-045 | 5% HNO₃ |
| QC Type | 125 mL | 500 mL | Purpose |
|---|---|---|---|
| ICV (Initial Calibration Verification) | 140-115-011 | 140-115-015 | Independent-source calibration check — Set 1 |
| ICV — Set 2 | 140-115-021 | 140-115-025 | Alternative ICV set |
| CRQL (Contract Required Quantitation Limit) | 140-117-021 | 140-117-025 | Quantitation limit verification |
| CRDL (Contract Required Detection Limit) | 140-117-011 | 140-117-015 | Detection limit verification |
| Interference Check Standards | 140-119-051 | 140-119-055 | Spectral interference verification |
EPA 200.7 compliant set for drinking water, wastewater, soil, and sediment analysis.
| Element(s) | Concentration | Set |
|---|---|---|
| Ag, Be, Cd | 5 µg/mL | Set A & B |
| Cr | 20 µg/mL | Set A & B |
| Cu | 25 µg/mL | Set A & B |
| Co, Mn, Ni | 50 µg/mL | Set A & B |
| Zn | 55 µg/mL | Set A & B |
| Fe | 100 µg/mL | Set A & B |
| Al, As, Ba | 200 µg/mL | Set A & B |
| Concentration Range | Typical Application | Dilution | Accuracy |
|---|---|---|---|
| 5–10 µg/mL | Drinking water | 1:10 | ±2% |
| 50–100 µg/mL | Wastewater | 1:5 | ±3% |
| 1,000 µg/mL | Soil | Required | ±5% |
| 10,000 µg/mL | Industrial | Required | ±5% |
EPA 200.8 is designed for ultra-trace element analysis at ppb and ppt levels by ICP-MS. Isotope-selective measurement is supported.
| Element | Oral PDE Limit (daily) | Catalog No. |
|---|---|---|
| Arsenic (As) | 1.5 µg/day | 140-131-031 |
| Cadmium (Cd) | 5 µg/day | 140-131-041 |
| Lead (Pb) | 5 µg/day | 140-131-051 |
| Mercury (Hg) | 15 µg/day | 140-131-021 |
| Content | Concentration (each element) | Catalog No. |
|---|---|---|
| Pd, Pt, Ir, Os, Rh, Ru, Au | 100 ppm | 140-131-061 |
USP 232 Class 1 and USP 2232 platinum group metal standards for elemental impurity analysis in drug substances and drug products. Applicable PDE limits vary by product category and route of administration — contact our technical team for guidance.
| Product | Scope | Application | Catalog No. |
|---|---|---|---|
| Groundwater Standards Low | Low-concentration trace metals | Groundwater monitoring | 140-025-034 |
| Groundwater Standards High | High concentration; contamination analysis | Contaminated groundwater | 140-025-035 |
| Wastewater Standards Low | Trace-level metals | Treatment plant effluent monitoring | 140-025-037 |
| Wastewater Standards High | 30+ elements, high concentration | Industrial wastewater discharge | 140-025-038 |
| TCLP Standards | Toxicity Characteristic Leaching Procedure | Hazardous waste classification | 140-107-031 / 032 / 035 |
TCLP standards are required for hazardous waste characterization under EPA Method 1311. Contact us to confirm the appropriate catalog number for your regulatory requirement.
Pharmaceutical Quality Control
All standards needed for elemental impurity analysis in drug substances and finished products are available from a single source.
Custom-Prepared Standards
SCP Science produces custom-formulated standards at its A2LA-accredited facility. Delivered with full NIST traceability documentation.
Certification & Quality
SCP Science standards are produced in an ISO/IEC 17025 accredited laboratory and certified under ISO Guide 34.
Applications
FAQ
EPA 200.7 is the ICP-OES method for water analysis, providing quantitation at the ppm (mg/L) level. EPA 200.8 is designed for ICP-MS, enabling measurements down to ppb (µg/L) and ppt (ng/L). The two methods require different calibration standard sets, ICV solutions and QC acceptance criteria. Environmental laboratories typically maintain separate standard sets for each method.
ICV (Initial Calibration Verification) confirms calibration accuracy using an independent standard from a different lot or manufacturer immediately after calibration. CCV (Continuing Calibration Verification) is run every 10 samples throughout the analysis to ensure the instrument remains within ±10% of the true value. PlasmaCAL® multi-element standards include dedicated ICV/CCV mixes aligned to EPA 200.7 and 200.8 requirements.
CRQL (Contract Required Quantitation Limit) is the minimum concentration a laboratory must reliably quantify under contract terms. CRDL (Contract Required Detection Limit) is the minimum detectable concentration. PlasmaCAL® standards are formulated at concentrations that allow laboratories to achieve EPA CRQL and CRDL levels for all listed elements, with low-level mixes available for trace analysis near detection limits.
Yes. PlasmaCAL® offers USP 232/233-specific multi-element mixes covering Class 1 (Cd, Pb, As, Hg), Class 2A and 2B, and Class 3 elemental impurities. Standards are prepared in matrices compatible with pharmaceutical sample digests and come with Certificates of Analysis traceable to NIST SRM 3100-series primary standards.
Shelf life is calculated from the date of manufacture and is printed on each bottle label and CoA. Unopened standards remain stable for 24 months when stored at 15–25°C, protected from direct light. After opening, use within 15 months. Each bottle is delivered with a tamper-evident cap; if storage conditions have been compromised, the standard should be returned or disposed of.
Quote & Info
Contact our technical team for pre-sales consultation, sample requests or pricing. Over 25 years of expertise in analytical instrumentation.
